Regulation of activating protein-4-associated metastases of non-small cell lung cancer cells by miR-144

摘要: Activating protein-4 (AP4) has been recently shown to regulate the cancer metastases in some cancers including non-small cell lung (NSCLC). Specifically, AP4 regulates mTor/p21 and transforming growth factor β (TGFβ) receptor signaling pathway increase an epithelial-mesenchymal transition process augment invasiveness. Nevertheless, how is regulated NSCLC not studied. Here, we showed that specimens from patients, levels of miR-144 were significantly decreased increased, compared paired non-tumor tissue. The inversely correlated patients’ specimens. Bioinformatics analyses revealed targeted 3′-UTR mRNA inhibit its translation, confirmed by luciferase-reporter assay. Moreover, overexpression inhibited AP4-mediated invasiveness, while depletion increased invasiveness cells. Together, our data suggest suppression may be cause AP4, as well augmented metastases, NSCLC.