Plasma BDNF concentration, Val66Met genetic variant and depression-related personality traits.
作者： A. Terracciano , B. Martin , D. Ansari , T. Tanaka , L. Ferrucci
DOI: 10.1111/J.1601-183X.2010.00579.X
关键词: Internal medicine 、 Big Five personality traits 、 Clinical psychology 、 Personality 、 Brain-derived neurotrophic factor 、 Neuroticism 、 Longitudinal study 、 Psychology 、 Depression (differential diagnoses) 、 Extraversion and introversion 、 Endocrinology 、 Conscientiousness
摘要: Brain‐derived neurotrophic factor (BDNF) regulates synaptic plasticity and neurogenesis, and BDNF plasma and serum levels have been associated with depression, Alzheimer's disease, and other psychiatric and neurodegenerative disorders. In a relatively large community sample, drawn from the Baltimore Longitudinal Study of Aging (BLSA), we examine whether BDNF plasma concentration is associated with the Val66Met functional polymorphism of the BDNF gene (n= 335) and with depression‐related personality traits …
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