Palladium-N-heterocyclic carbene (NHC) catalyzed C–N bond formation in a continuous flow microreactor. Effect of process parameters and comparison with batch operation
作者： Angelo Pommella , Giovanna Tomaiuolo , Anthony Chartoire , Sergio Caserta , Giuseppe Toscano
DOI: 10.1016/J.CEJ.2013.03.070
关键词: Microreactor 、 Inorganic chemistry 、 Buchwald–Hartwig amination 、 Palladium 、 Reaction rate 、 Photochemistry 、 Chemistry 、 Chemical kinetics 、 Catalysis 、 Coupling reaction 、 Reagent
摘要: Abstract In this work, the Buchwald–Hartwig aryl amination is reported in a home-made continuous plug flow tube microreactor, using homogeneous well-defined palladium-N-heterocyclic carbene (NHC) complex. The microreactor enabled 100% conversion of reagents within 30 min, even at very low catalyst concentrations. A direct comparison between batch and reactions described shows that reaction faster than case. An investigation influence operating parameters on was carried out. Increasing temperature allowed reagents; moreover, no effect performance found by changing diameter. dependence kinetics [Pd(NHC)] pre-catalyst concentrations investigated based initial rates. resulting expression for rate showed some similarities with one palladium–phosphine catalyst, but also important differences.
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