Regulation of survivin and CDK4 by Epstein-Barr virus encoded latent membrane protein 1 in nasopharyngeal carcinoma cell lines.
作者： Mi Dan AI , Li Li LI , Xiao Rong ZHAO , Yong WU , Jian Ping GONG
关键词: Cyclin-dependent kinase 4 、 Biology 、 Cancer research 、 Cell growth 、 Virology 、 Cell cycle 、 Epstein–Barr virus 、 Nasopharyngeal carcinoma 、 Survivin 、 Nasopharyngeal neoplasm 、 Apoptosis
摘要: Latent membrane protein 1 (LMP1), an important encoded by Epstein Barr virus (EBV), has been implied to link with the pathogenesis of nasopharyngeal carcinoma (NPC). Its dual effects increasing cell proliferation and inhibiting apoptosis have confirmed. In this study, we showed that expression Survivin CDK4 in CNE-LMP1, a LMP1 positive NPC epithelial line, is higher than negative line-CNE1, dosage-dependent. Although it was reported specifically expressed cycle G2/M phase, our studies suggested could promote G0/G1, S phase. It also be accumulated more nuclei triggered LMP1. More interestingly, form complex CNE-LMP1 rather CNE1, which demonstrated interaction between these two proteins promoted These results strongly role regulation may shed some light on mechanism research NPC.
nature.com
sci-hub.se 参考文章(39)
Huen Ds, Rowe M, Croom-Carter D, Henderson Sa, The Epstein-Barr virus latent membrane protein-1 (LMP1) mediates activation of NF-kappa B and cell surface phenotype via two effector regions in its carboxy-terminal cytoplasmic domain. Oncogene. ,vol. 10, pp. 549- 560 ,(1995)
Nanney Lb, Luongo C, DuBois Rn, Beauchamp Rd, Lamps L, Zhang T, Heppner Kj, Concurrent overexpression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple intestinal neoplasia (min) mice and human familial adenomatous polyposis patients Cancer Research. ,vol. 57, pp. 169- 175 ,(1997)
Dario C. Altieri, Fengzhi Li, The cancer antiapoptosis mouse survivin gene: characterization of locus and transcriptional requirements of basal and cell cycle-dependent expression. Cancer Research. ,vol. 59, pp. 3143- 3151 ,(1999)
Elizabeth G. Snyderwine, Cunping Qiu, Liang Shan, Minshu Yu, Deregulation of the cyclin D1/Cdk4 retinoblastoma pathway in rat mammary gland carcinomas induced by the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Cancer Research. ,vol. 63, pp. 5674- 5678 ,(2003)
Fengzhi Li, Grazia Ambrosini, Emily Y. Chu, Janet Plescia, Simona Tognin, Pier Carlo Marchisio, Dario C. Altieri, Control of apoptosis and mitotic spindle checkpoint by survivin. Nature. ,vol. 396, pp. 580- 584 ,(1998) , 10.1038/25141
Julian Downward, Nicholas R. Lemoine, Luis M. Martins, Jian Zhao, Tencho Tenev, The ubiquitin-proteasome pathway regulates survivin degradation in a cell cycle-dependent manner Journal of Cell Science. ,vol. 113, pp. 4363- 4371 ,(2000) , 10.1242/JCS.113.23.4363
GM Mælandsmo, VA Flørenes, E Hovig, T Øyjord, O Engebraaten, R Holm, A-L Børresen, Ø Fodstad, Involvement of the pRb/p16/cdk4/cyclin D1 pathway in the tumorigenesis of sporadic malignant melanomas. British Journal of Cancer. ,vol. 73, pp. 909- 916 ,(1996) , 10.1038/BJC.1996.181
Xin Song, Midan Ai, Xiaoxi Chen, Xiyun Deng, Yongguang Tao, Jianping Gong, Qiao Wu, Ya Cao, Regulation of c-Jun/JunB heterodimers mediated by Epstein-Barr virus encoded latent membrane protein 1 on p16 Chinese Science Bulletin. ,vol. 49, pp. 676- 683 ,(2004) , 10.1007/BF03184264
Constantine S. Mitsiades, Teru Hideshima, Nicholas Mitsiades, Nikhil C. Munshi, Toshiaki Hayashi, Dharminder Chauhan, Paul Richardson, Yu-Tzu Tai, Masaharu Akiyama, Kenneth C. Anderson, Nuclear Factor-κB p65 Mediates Tumor Necrosis Factor α-induced Nuclear Translocation of Telomerase Reverse Transcriptase Protein Cancer Research. ,vol. 63, pp. 18- 21 ,(2003)
Jose A. Rodrı́guez, Simone W. Span, Carlos G.M. Ferreira, Frank A.E. Kruyt, Giuseppe Giaccone, CRM1-Mediated Nuclear Export Determines the Cytoplasmic Localization of the Antiapoptotic Protein Survivin Experimental Cell Research. ,vol. 275, pp. 44- 53 ,(2002) , 10.1006/EXCR.2002.5492