Early steroid withdrawal in renal transplantation with tacrolimus dual therapy: a pilot study

摘要: Early steroid withdrawal in renal transplantation with tacrolimus dual therapy: a pilot study. Boots JM, Christiaans MH, Van Duijnhoven EM, Suylen RJ, Hooff JP. Department of Nephrology, University Hospital Maastricht, PO Box 5800, 6202 AZ The Netherlands. jboo@groupwise.azm.nl. BACKGROUND: With tacrolimus-based immunosuppression, it appears safe to withdraw steroids 3 6 months after transplantation. We hypothesized whether could also be safely withdrawn early METHODS: Sixty-two patients (first or second transplant, no previous immunological failure, and current panel reactive human leucocyte antigen [HLA] antibodies [PRA] 0.70). incidence infections was comparable ( P>0.10). new-onset diabetes mellitus, defined as the use antidiabetic medication, 8.0 (STOP) versus 30.3% (TAP) (P =0.04). All cases occurred STOP group 1 year, while all TAP first 4 P<0.001). CONCLUSIONS: Compared tapering months, stopping week posttransplantation results patient graft survival similar acute rejections. may reduced. immunosuppressive benefit adding 10 mg prednisolone seems limited.