The Multistage Model with a Time‐Dependent Dose Pattern: Applications to Carcinogenic Risk Assessment1
作者： Kenny S. Clump , Richard B. Howe
DOI: 10.1111/J.1539-6924.1984.TB00136.X
关键词: Single measure 、 Cancer risk assessment 、 Statistics 、 Risk assessment 、 Cumulative dose 、 Dose rate 、 Bioassay 、 Toxicology 、 Medicine 、 Carcinogen
摘要: A cancer risk assessment methodology based upon the Armitage–Doll multistage model of is applied to animal bioassay data. The method utilizes exact time-dependent dose pattern used in a rather than some single measure such as average rate or cumulative dose. can be predict risks from arbitrary exposure patterns including, for example, intermittent and short-term occurring at an age. illustrated by applying it National Cancer Institute ethylene dibromide which rates were modified several times during course experiment.
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