Self-Guided Online Cognitive Behavioral Strategies for Chemotherapy-Induced Peripheral Neuropathy: A Multicenter, Pilot, Randomized, Wait-List Controlled Trial.

摘要: Abstract The purpose of this pilot, parallel, randomized controlled trial was to examine the efficacy a self-guided online cognitive and behaviorally-based pain management intervention (Proactive Self-Management Program for Effects Cancer Treatment [PROSPECT]) reduce “worst” individuals with chronic painful chemotherapy-induced peripheral neuropathy (CIPN). Secondary outcomes included “average” pain, nonpainful CIPN symptom severity, impression change, interference. Sixty patients were recruited from 5 outpatient academic community cancer centers. Patients in 1:1 ratio receive either 8 weeks PROSPECT or usual care. A 7-day electronic intensity diary standardized measures interference, administered pre/post intervention. Postintervention mean scores evaluated between groups using analysis covariance adjusting baseline. Individuals who received (n = 19) had significantly greater improvements “worst pain” compared receiving care (n = 19; P = .046, d = .58). There no significant differences secondary (n = 42). larger, adequately powered study testing is needed determine if may be sustained, evaluate effect on outcomes, identify mediators intensity-related improvement. Perspective This explores an 8-week behavioral CIPN. Intervention use resulted than alone. findings provide preliminary support nonpharmacological