Silicon-[18F]Fluorine Radiochemistry: Basics, Applications and Challenges
作者： Carmen Wängler , Alexey Kostikov , Jun Zhu , Joshua Chin , Björn Wängler
DOI: 10.3390/APP2020277
关键词: Fluorine 、 Pet imaging 、 Positron emission tomography 、 Chemistry 、 Nanotechnology 、 Bond formation 、 Silicon 、 Radiochemistry 、 Bioactive molecules
摘要: Silicon-[18F]fluorine (Si-18F) radiochemistry has recently emerged alongside other unconventional approaches such as aluminum-18F and boron-18F based labeling strategies, reshaping the landscape of modern 18F-radiochemistry. All these novel methodologies are driven by demand for more convenient 18F-labeling procedures to further disseminate one most sophisticated imaging technologies, Positron Emission Tomography (PET). The PET methodology requires special radionuclides 18F (one prominent examples) be introduced into bioactive molecules. Si-18F contributed greatly towards development new radiopharmaceuticals imaging. Herein, we describe radiochemical basics bond formation, application tracers imaging, additionally, inherent chemical intricacies this methodology.
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