SNPs in genes encoding G proteins in pharmacogenetics.

摘要: Heterotrimeric guanine-binding proteins (G proteins) transmit signals from the cell surface to intracellular signal cascades and are involved in various physiological pathophysiological processes. Polymorphisms genes GNB3 (encoding Gβ3 subunit), GNAS Gαs subunit) GNAQ Gαq have been primary focus of investigation. these could be associated with different complex phenotypes underlining that alterations G-protein signaling can cause multiple disorders. G present a point convergence or ‘bottleneck’ between receptors effectors, thus making them sensible tool for pharmacogenetic studies. The studies performed date mostly demonstrate an association polymorphisms response therapy occurrence adverse drug effects. Therefore, encoding subunits may help individualize treatment diseases regard both e...