Reevaluation of T cell subset monitoring in cyclosporine-treated renal allograft recipients.

摘要: The predictive value of peripheral blood T cell subset monitoring in renal allograft recipients has been questionable, and there no information concerning the correlation changes with clinical event related to cyclosporine nephrotoxicity. This study was conducted investigate usefulness serial 34 consecutive transplant patients treated by determining total lymphocyte count counts using Leu-4, Leu-3ab, Leu-2a monoclonal antibodies flow cytometry up 6 months after transplantation. absolute all cells were lower transplanted than those normal controls, but not different from hemodialysis patients. During infection, helper/suppressor (H/S) ratio counts, except for suppressor cells, decreased significantly. Within one week prior rejection, also Furthermore, before steroid-resistant rejection significantly steroid-responsive rejection. In contrast, increased within nephrotoxicity being diagnosed; H/S correlated or toxicity. These results indicate that is associated events recipients, can provide valuable differentiation nephrotoxicity, predicting outcome