Correlation of Mycobacterium Tuberculosis Specific and Non-Specific Quantitative Th1 T-Cell Responses with Bacillary Load in a High Burden Setting
作者： Grant Theron , Jonny Peter , Laura Lenders , Richard van Zyl-Smit , Richard Meldau
DOI: 10.1371/JOURNAL.PONE.0037436
关键词: Sputum 、 Tuberculosis 、 Non specific 、 Immunology 、 T cell 、 Medicine 、 Mycobacterium tuberculosis 、 Correlation 、 Response to treatment 、 Culture conversion
摘要: Background Measures of bacillary load in patients with tuberculosis (TB) may be useful for predicting and monitoring response to treatment. The relationship between quantitative T-cell responses mycobacterial remains unclear. We hypothesised that, a HIV-prevalent high burden setting, the magnitude antigen-specific non-specific IFN-γ would correlate (a) bacterial (b) culture conversion undergoing
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