Cholinergic anti-inflammatory pathway activity and High Mobility Group Box-1 (HMGB1) serum levels in patients with rheumatoid arthritis.

作者: Richard S. Goldstein , Annette Bruchfeld , Lihong Yang , Abdul R. Qureshi , Margot Gallowitsch-Puerta

DOI: 10.2119/2006-00108.GOLDSTEIN

关键词: ImmunologyCytokineInternal medicineCase-control studyEndocrinologyCholinergicVagus nerveCholinergic anti-inflammatory pathwayRheumatoid arthritisArthritisPathogenesisMedicine

摘要: High Mobility Group Box-1 (HMGB1) is a cytokine implicated in the pathogenesis of rheumatoid arthritis (RA) and other inflammatory diseases. The cholinergic anti-inflammatory pathway, vagus nerve-dependent mechanism, inhibits HMGB1 release experimental disease models. Here, we examine relationship between nerve activity patients with RA. We compared RR interval variability, an index cardiac vagal modulation, hsCRP serum levels, scores thirteen RA eleven age- sex-matched controls. In patients, levels were elevated as controls (HMGB1 = 71 ng/mL [45–99] vs. 18 [0–40], P < 0.0001; 14.5 mg/L [0.7–59] 1 [0.4–2.9], 0.001). variability was significantly decreased (HF 38 msec2 [14–80] 288 [38–364], rMSSD 20.9 ± 9.79 msec, 52.6 35.3 0.01). related (rho −0.49, correlated (DAS-28) (P 0.004). study design does not enable determination causality, but results are consistent hypothesis that pathway associated increased

参考文章(32)
P.L.C.M. van Riel, G. Stucki, J.H. Fransen, Rheumatoid Arthritis Measures. Arthritis & Rheumatism. ,vol. 49, pp. 214- 224 ,(2003)
Valentin A. Pavlov, Hong Wang, Christopher J. Czura, Steven G. Friedman, Kevin J. Tracey, The Cholinergic Anti-inflammatory Pathway: A Missing Link in Neuroimmunomodulation Molecular Medicine. ,vol. 9, pp. 125- 134 ,(2003) , 10.1007/BF03402177
R. Kokkola, J. Li, E. Sundberg, A.-C. Aveberger, K. Palmblad, H. Yang, K. J. Tracey, U. Andersson, H. Erlandsson Harris, Successful treatment of collagen-induced arthritis in mice and rats by targeting extracellular high mobility group box chromosomal protein 1 activity Arthritis & Rheumatism. ,vol. 48, pp. 2052- 2058 ,(2003) , 10.1002/ART.11161
Harun Evrengül, Dursun Dursunoglu, Veli Cobankara, Bülent Polat, Deniz Seleci, Sibel Kabukçu, Asuman Kaftan, Ender Semiz, Mustafa Kilic, Heart rate variability in patients with rheumatoid arthritis Rheumatology International. ,vol. 24, pp. 198- 202 ,(2004) , 10.1007/S00296-003-0357-5
Kevin J. Tracey, The inflammatory reflex Nature. ,vol. 420, pp. 853- 859 ,(2002) , 10.1038/NATURE01321
Tore K Kvien, Till Uhlig, Sigrid Ødegård, Marte S Heiberg, Epidemiological aspects of rheumatoid arthritis: the sex ratio Annals of the New York Academy of Sciences. ,vol. 1069, pp. 212- 222 ,(2006) , 10.1196/ANNALS.1351.019
J. Andrew Taylor, Deborah L. Carr, Christopher W. Myers, Dwain L. Eckberg, Mechanisms Underlying Very-Low-Frequency RR-Interval Oscillations in Humans Circulation. ,vol. 98, pp. 547- 555 ,(1998) , 10.1161/01.CIR.98.6.547
Michael T. Lotze, Kevin J. Tracey, High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal. Nature Reviews Immunology. ,vol. 5, pp. 331- 342 ,(2005) , 10.1038/NRI1594
Carlos Gonzalez-Juanatey, Javier Llorca, Ana Testa, Javier Revuelta, Carlos Garcia-Porrua, Miguel A. Gonzalez-Gay, Increased prevalence of severe subclinical atherosclerotic findings in long-term treated rheumatoid arthritis patients without clinically evident atherosclerotic disease. Medicine. ,vol. 82, pp. 407- 413 ,(2003) , 10.1097/01.MD.0000101572.76273.60
Thomas R. Bernik, Steven G. Friedman, Mahendar Ochani, Robert DiRaimo, Luis Ulloa, Huan Yang, Samridhi Sudan, Christopher J. Czura, Svetlana M. Ivanova, Kevin J. Tracey, Pharmacological Stimulation of the Cholinergic Antiinflammatory Pathway Journal of Experimental Medicine. ,vol. 195, pp. 781- 788 ,(2002) , 10.1084/JEM.20011714