作者: Richard S. Goldstein , Annette Bruchfeld , Lihong Yang , Abdul R. Qureshi , Margot Gallowitsch-Puerta
DOI: 10.2119/2006-00108.GOLDSTEIN
关键词: Immunology 、 Cytokine 、 Internal medicine 、 Case-control study 、 Endocrinology 、 Cholinergic 、 Vagus nerve 、 Cholinergic anti-inflammatory pathway 、 Rheumatoid arthritis 、 Arthritis 、 Pathogenesis 、 Medicine
摘要: High Mobility Group Box-1 (HMGB1) is a cytokine implicated in the pathogenesis of rheumatoid arthritis (RA) and other inflammatory diseases. The cholinergic anti-inflammatory pathway, vagus nerve-dependent mechanism, inhibits HMGB1 release experimental disease models. Here, we examine relationship between nerve activity patients with RA. We compared RR interval variability, an index cardiac vagal modulation, hsCRP serum levels, scores thirteen RA eleven age- sex-matched controls. In patients, levels were elevated as controls (HMGB1 = 71 ng/mL [45–99] vs. 18 [0–40], P < 0.0001; 14.5 mg/L [0.7–59] 1 [0.4–2.9], 0.001). variability was significantly decreased (HF 38 msec2 [14–80] 288 [38–364], rMSSD 20.9 ± 9.79 msec, 52.6 35.3 0.01). related (rho −0.49, correlated (DAS-28) (P 0.004). study design does not enable determination causality, but results are consistent hypothesis that pathway associated increased