The protective effect of CDDO-Me on lipopolysaccharide-induced acute lung injury in mice.

作者: Tong Chen , Yi Mou , Jiani Tan , Linlin Wei , Yixue Qiao

DOI: 10.1016/J.INTIMP.2015.01.011

关键词: CytokineLung injuryLungPathogenesisIn vivoLipopolysaccharidePharmacologyImmunologyDexamethasoneProtein kinase BMedicine

摘要: CDDO-Me, initiated in a phase II clinical trial, is a potential useful therapeutic agent for cancer and inflammatory dysfunctions, whereas the therapeutic efficacy of CDDO-Me on LPS-…

参考文章(41)
Ida A. J. Giebelen, David J. van Westerloo, Gregory J. LaRosa, Alex F. de Vos, Tom van der Poll, Local stimulation of alpha7 cholinergic receptors inhibits LPS-induced TNF-alpha release in the mouse lung. Shock. ,vol. 28, pp. 700- 703 ,(2007) , 10.1097/SHK.0B013E318054DD89
Xiaozhe Zhang, Jianhua Li, Chi Chen, Xinxin Ci, Qinlei Yu, Xichen Zhang, Xuming Deng, Protective effect of abamectin on acute lung injury induced by lipopolysaccharide in mice. Fundamental & Clinical Pharmacology. ,vol. 25, pp. 700- 707 ,(2011) , 10.1111/J.1472-8206.2010.00896.X
S. Van Laecke, W. Van Biesen, R. Vanholder, The paradox of bardoxolone methyl: a call for every witness on the stand? Diabetes, Obesity and Metabolism. ,vol. 17, pp. 9- 14 ,(2015) , 10.1111/DOM.12356
Balachandar Venkatesan, Anthony J. Valente, Sumanth D. Prabhu, Prakashsrinivasan Shanmugam, Patrice Delafontaine, Bysani Chandrasekar, EMMPRIN activates multiple transcription factors in cardiomyocytes, and induces interleukin-18 expression via Rac1-dependent PI3K/Akt/IKK/NF-κB andMKK7/JNK/AP-1 signaling Journal of Molecular and Cellular Cardiology. ,vol. 49, pp. 655- 663 ,(2010) , 10.1016/J.YJMCC.2010.05.007
Rajesh K. Thimmulappa, Ralph J. Fuchs, Deepti Malhotra, Catherine Scollick, Kassim Traore, Jay H. Bream, Michael A. Trush, Karen T. Liby, Michael B. Sporn, Thomas W. Kensler, Shyam Biswal, Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils Antioxidants & Redox Signaling. ,vol. 9, pp. 1963- 1970 ,(2007) , 10.1089/ARS.2007.1745
Chiu-Yuan Chen, Wen-Huang Peng, Kuen-Daw Tsai, Shih-Lan Hsu, Luteolin suppresses inflammation-associated gene expression by blocking NF-κB and AP-1 activation pathway in mouse alveolar macrophages Life Sciences. ,vol. 81, pp. 1602- 1614 ,(2007) , 10.1016/J.LFS.2007.09.028
Kil-Nam Kim, Yeong-Jong Ko, Min-Cheol Kang, Hye-Mi Yang, Seong Woon Roh, Tatsuya Oda, You-Jin Jeon, Won-Kyo Jung, Soo-Jin Heo, Weon-Jong Yoon, Daekyung Kim, Anti-inflammatory effects of trans-1,3-diphenyl-2,3-epoxypropane-1-one mediated by suppression of inflammatory mediators in LPS-stimulated RAW 264.7 macrophages. Food and Chemical Toxicology. ,vol. 53, pp. 371- 375 ,(2013) , 10.1016/J.FCT.2012.12.021
Meixia Huo, Ruijie Gao, Lanxiang Jiang, Xiurui Cui, Lingxin Duan, Xuming Deng, Shuang Guan, Jingyuan Wei, Lanan Wassy Soromou, Haihua Feng, Gefu Chi, Suppression of LPS-induced inflammatory responses by gossypol in RAW 264.7 cells and mouse models International Immunopharmacology. ,vol. 15, pp. 442- 449 ,(2013) , 10.1016/J.INTIMP.2013.01.008
Won Sun Park, Won-Kyo Jung, Da-Young Lee, Chisook Moon, Sung Su Yea, Sae-Gwang Park, Su-Kil Seo, Cheol Park, Yung Hyun Choi, Gi-Young Kim, Jung Sik Choi, Il-Whan Choi, Cilostazol protects mice against endotoxin shock and attenuates LPS-induced cytokine expression in RAW 264.7 macrophages via MAPK inhibition and NF-κB inactivation: Not involved in cAMP mechanisms International Immunopharmacology. ,vol. 10, pp. 1077- 1085 ,(2010) , 10.1016/J.INTIMP.2010.06.008