Cathepsins: fundamental effectors of endolysosomal proteolysis.

摘要: Intracellular protein degradation is a universal feature of eukaryotic cells and vital for nutrition, turnover, intracellular signaling, development other major physiological processes like antigen presentation immunity. One the compartments proteolysis endosome-lysosome system. The latter offers highly orchestrated, vesicular pathway transport ultimate in lysosomes. Though lysosomes are classical organelles complex, multi-enzymatic degradation, it increasingly evident that endosomes conduct much more than mere functions. Endosomes contain significant levels proteases cathepsins sites potent proteolysis. Further, discrete classes harbor specific perform selective exclusive Hence, extra-lysosomal proteolytic machinery within endocytic enjoys spatial temporal control over review outlines structural association function(s) endolysosomal cathepsins.