Investigating the hows and whys of DNA endoreduplication

摘要: Endoreduplication is a form of nuclear polyploidization that results in multiple, uniform copies chromosomes. This process common plants and animals, especially tissues with high metabolic activity, it generally occurs cells are terminally differentiated. In plants, endoreduplication well documented the endosperm cotyledons developing seeds, but also many throughout plant. It thought provides mechanism to increase level gene expression, function this has not been thoroughly investigated. Numerous observations have made endoreduplication, or at least extra cycles S-phase, as consequence mutations genes controlling several aspects cell cycle regulation. However, until recently there were few studies directed molecular mechanisms responsible for specialized cycle. suggested requires nothing more elaborate than loss M-phase cyclin-dependent kinase activity oscillations S-phase kinase.