Efficacy of a new nutraceutical formulation (CHETOGERD®) in patients with nonerosive reflux disease (NERD): a prospective observational study.

摘要: Nonerosive reflux disease (NERD) is a gastrointestinal disorder that leads to symptoms such as heartburn and regurgitation without visible esophageal mucosal injury, it treated with proton-pump inhibitors (PPIs). CHETOGERD® gel or orosoluble (oro) formulations—an association of natural active ingredient: hyaluronic acid, altea, malva, apple TM, Aloe vera, l-triptophan, calcium gluconate, sodium bicarbonate, Musa paradisiaca)—may be an alternative coadjutant treatment in patients NERD. The aim the study was evaluate, prospectively, efficacy oro inducing symptom’s reduction remission, consecutive Patients were divided two groups oro, 3 sachets/day for 3 months, decreased 1 sachet/day other 3 months. Symptoms evaluated at baseline, 6 months using questionnaire (RDQ). Symptoms’ remission defined retrosternal pain burning, epigastric acid sensation mouth. Frequency, distribution analyses non-parametric tests used statistical analysis. Results considered statistically significant p values < 0.05. Four hundred twenty-three (M/F 240/183; mean age 50 years) diagnosed NERD consecutively enrolled. 146 underwent therapy gel, while 277 oro. 108 from first group 172 second completed follow up 100 each follow-up 6 months. Both formulations able significantly reduce frequency intensity analysed RDQ. No adverse events reported. are valid alternatives control nonerosive disease.