The use of amino acid based CAPD fluid in chronic renal failure

摘要: CAPD is a major treatment for end-stage renal disease. A dialysis fluid in the peritoneum, changed several times day, uses glucose, an effective osmotic agent but which contributes to hyperlipidaemia and malnutrition. Amino acids have been investigated as alternative glucose short long-term studies described literature. One two % amino are maximally absorbed into blood after 2–4 h decrease initial concentrations 6 unless constituents excess e.g. phenylalanine methionine. These changes those other metabolites similar marked post-prandial effect. In up 12 weeks duration, one or exchanges of 1% daily were well tolerated with modest nutritional improvement (e.g. acids, transferrin total body nitrogen), small decreases hyperlipidaemia, no clinical problems due loss appetite, increase urea, overhydration acidosis. Both these less favourable suggest could occur higher multiple also unsuitable patients. Slight ultrafiltration increased protein losses dialysate reversible effect on permeability. Our that acid complement activation by pathway generation prostaglandin E2, increases However, exceed all losses, although percentage utilisation not known. based fluids patients high low calorie diets requiring more dialysis. Fluids containing buffering capacity lower certain indicated.