The effect of udenafil on the hemodynamics of healthy male volunteers administered tamsulosin.
作者： Min-Gul Kim , Jung-Ryul Kim , Bo-Hyung Kim , Kyoung Soo Lim , Sang-Goo Shin
DOI: 10.1185/03007995.2013.792792
关键词: Anesthesia 、 Hemodynamics 、 Drug interaction 、 Tamsulosin 、 Medicine 、 Blood pressure 、 Udenafil 、 Placebo 、 Confidence interval 、 Pharmacokinetics
摘要: AbstractObjective:The purpose of this study is to evaluate the hemodynamic interactions between udenafil and tamsulosin.Methods:After a placebo lead-in period, 27 healthy volunteers received 200 mg udenafil + tamsulosin placebo, +0.4 mg tamsulosin, or tamsulosin. Blood pressure pulse rate (PR) were measured at 15 time points from 0 24 hours.Results:A single dose udenafil, when administered with multiple tamsulosin doses, produced statistically significant increases in PR (mean: 10.7; 95% confidence interval: 5.3, 16.2 bpm; p < 0.001) compared an placebo. Systolic diastolic blood measurements remained unchanged. Two subjects who took had decrease standing systolic (SBP) greater than 30 mmHg comparison their baseline SBP; however, frequency SBP baseline, there was no ...
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