IL-1beta-IL-1Ra CHIMERA AND METHODS OF USING THE SAME

作者: Charles A. Dinarello , Peleg Rider , Eli Lewis

DOI:

关键词: BiologyPolynucleotideChimera (genetics)InflammationPeptideBiochemistry

摘要: The present invention providesachimera protein made ofamino acid residuesderived from IL-1beta propeptideand the IL-1Ra mature peptide and polynucleotides encoding protein. also provides usages of in pharmaceutical compositions that treat inflammation.

参考文章(10)
John Puskas, Mark Sullivan, John G. Frelinger, Baek Kim, Protease activated cytokines ,(2011)
Thomas M. Barnes, Jinzhao Hou, Bracken M. King, Chimeric il-1 receptor type i agonists and antagonists ,(2011)
Mohammed F. Shamji, Helawe Betre, Virginia B. Kraus, Jun Chen, Ashutosh Chilkoti, Rajeswari Pichika, Koichi Masuda, Lori A. Setton, Development and characterization of a fusion protein between thermally responsive elastin-like polypeptide and interleukin-1 receptor antagonist: sustained release of a local antiinflammatory therapeutic. Arthritis & Rheumatism. ,vol. 56, pp. 3650- 3661 ,(2007) , 10.1002/ART.22952
Charles A. Dinarello, Interleukin-1, Interleukin-1 Receptors and Interleukin-1 Receptor Antagonist International Reviews of Immunology. ,vol. 16, pp. 457- 499 ,(1998) , 10.3109/08830189809043005
Charles A. Dinarello, Anna Simon, Jos W. M. van der Meer, Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases Nature Reviews Drug Discovery. ,vol. 11, pp. 633- 652 ,(2012) , 10.1038/NRD3800
M Irmler, S Hertig, H R MacDonald, R Sadoul, J D Becherer, A Proudfoot, R Solari, J Tschopp, Granzyme A is an interleukin 1 beta-converting enzyme. Journal of Experimental Medicine. ,vol. 181, pp. 1917- 1922 ,(1995) , 10.1084/JEM.181.5.1917
Peleg Rider, Yaron Carmi, Rami Yossef, Ofer Guttman, Hadar Eini, Tania Azam, Charles A. Dinarello, Eli C. Lewis, IL-1 Receptor Antagonist Chimeric Protein: Context-Specific and Inflammation-Restricted Activation Journal of Immunology. ,vol. 195, pp. 1705- 1712 ,(2015) , 10.4049/JIMMUNOL.1501168
Nathan Geething, Benjamin Spink, Chia-Wei Wang, Jeffrey L. Cleland, Joshua Silverman, Wayne To, Volker Schellenberger, Willem P. Stemmer, Interleukin-1 receptor antagonist compositions and methods of making and using same ,(2010)