Oligomeric biosurfactants in dermatocosmetic compositions

作者: Lili Fan , Donald R. Owen

DOI:

关键词: FibroblastCell turnoverMicelleAqueous solutionExtracellularMatrix (biology)ChromatographyMaterials scienceBiochemistry

摘要: Oligomeric acylated biosurfactants (“OABs”) having low critical micelle concentrations of from about 1.0 ppm to 200 ppm, preferably less than 50 in an aqueous solution Minimal Essential Media that can lower the surface tension MEM environment dynes/cm 2 and have ability increase metabolic soluble proteins and/or synthesis extracellular skin matrix rates cell turnover while at same time exhibiting comparatively toxicity—preferably, LD greater 37 year-old female fibroblast cells. Another aspect present invention is directed use OABs formulations are topically-applied, by which meant formulation placed direct contact with skin, hair nails as well mucosa eyes, ears, nose, mouth, anus vagina.

参考文章(17)
J. Vincent Edwards, Larry R. Mclean, Peptide lung surfactants and therapeutic combinations ,(1993)
Frank Swenson, Christopher Hawk, David Tyler, John L. Grimsich, Kenneth Beckman, Biocidal methods and compositions ,(2001)
Elizabeth Ann Jewell-Motz, Donald Lynn Bissett, Methods for regulating the condition of mammalian keratinous tissue ,(2000)
Shogo Koshida, Hokari Tsuda, Yumiko Oka, Yohei Hirai, Kyoko Takebe, Keiko Tochigi, Toko Shinagawa, Kayoko Murakami, Oligopeptides for promoting hair growth ,(2002)
Halldis Hellebust, Helge Tolleshaug, Anders Høgset, Pål Rongved, Jo Klaveness, Magne Solbakken, Dagfinn Løvhaug, Lars Hoff, Anne Naevestad, Alan Cuthbertson, Improvements in or relating to diagnostic/therapeutic agents ,(1997)
Samuel Dufour, Magali Deleu, Katherine Nott, Bernard Wathelet, Philippe Thonart, Michel Paquot, Hemolytic activity of new linear surfactin analogs in relation to their physico-chemical properties. Biochimica et Biophysica Acta. ,vol. 1726, pp. 87- 95 ,(2005) , 10.1016/J.BBAGEN.2005.06.015