Allotype immunoglobulin enhances alkaline phosphatase activity: implications for the inflammatory response.

作者: Tetsuya Shinozaki , Hideomi Watanabe , Kenji Takagishi , Kenneth P.H. Pritzker

DOI: 10.1016/S0022-2143(98)90046-4

关键词: Placental alkaline phosphataseAlkaline phosphataseAntibodyMolecular biologyChemistryHorseradish peroxidaseAcid phosphataseBovine serum albuminImmunoglobulin GBiochemistryPhosphatase

摘要: To understand the interactions among components of immune/inflammation response, we studied effects immunoglobulins on phosphatase activity alkaline in vitro. Bovine intestinal was incubated with substrate presence allotypic and xenotypic immunoglobulin. We found that bovine but not rabbit immunoglobulin enhanced phosphatase. Similarly, human G placental activity. By enhancing activity, bound to may assist physiologic transport functions enhance resolution inflammatory response. Further, clinical conditions high concentrations, serum recorded have spuriously values.

参考文章(32)
T Gordon, Factors associated with serum alkaline phosphatase level Archives of Pathology & Laboratory Medicine. ,vol. 117, pp. 187- 190 ,(1993)
K. P. H. Pritzker, Yan Xu, T. Shinozaki, T. F. Cruz, Calcium pyrophosphate dihydrate (CPPD) crystal dissolution by alkaline phosphatase: interaction of alkaline phosphatase on CPPD crystals. The Journal of Rheumatology. ,vol. 22, pp. 117- 123 ,(1995)
Y. Xu, T. F. Cruz, K. P. H. Pritzker, Alkaline phosphatase dissolves calcium pyrophosphate dihydrate crystals. The Journal of Rheumatology. ,vol. 18, pp. 1606- 1610 ,(1991)
Frank W. Putnam, Isolation, characterization, and function Academic Press. ,(1960)
Ch. Weiss, W. Jelkmann, Functions of the Blood Human Physiology. pp. 402- 438 ,(1989) , 10.1007/978-3-642-73831-9_18
J. H. M. Wöltgens, Inorganic Pyrophosphatase in Mineralizing Hamster Molars Calcified Tissue International. ,vol. 16, pp. 201- 207 ,(1974) , 10.1007/BF02008227
Kazuyuki HIRANO, Yuichi IIIZUMI, Yukio MORI, Kazumi TOYOSHI, Mamoru SUGIURA, Shiro IINO, Role of alkaline phosphatase in phosphate uptake into brush border membrane vesicles from human intestinal mucosa. Journal of Biochemistry. ,vol. 97, pp. 1461- 1466 ,(1985) , 10.1093/OXFORDJOURNALS.JBCHEM.A135200