Retinitis pigmentosa: rod photoreceptor rescue by a calcium-channel blocker in the rd mouse
作者： Maria Frasson , Jose A. Sahel , Michel Fabre , Manuel Simonutti , Henri Dreyfus
DOI: 10.1038/13508
关键词: Retinitis pigmentosa 、 Diltiazem 、 Gene therapy of the human retina 、 Retinal degeneration 、 Degenerative disease 、 Ophthalmology 、 Medicine 、 Phosphodiesterase 、 Retinal regeneration 、 Calcium channel blocker
摘要: Retinitis pigmentosa is an inherited degenerative disease of photoreceptors leading to blindness. A well-characterized model for this provided by the retinal degeneration mouse, in which gene rod cGMP phosphodiesterase mutated, as some affected human families. We report that D-cis-diltiazem, a calcium-channel blocker also acts at light-sensitive cGMP-gated channels, rescued and preserved visual function mouse. The long record diltiazem prescription cardiology should facilitate design clinical trials forms retinitis pigmentosa.
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