Prognostic role of microscopically positive margins for primary gastrointestinal stromal tumors: a systematic review and meta-analysis
作者： Xiaofei Zhi , Baofei Jiang , Junbo Yu , Oluf Dimitri Røe , Jun Qin
DOI: 10.1038/SREP21541
关键词: GiST 、 Surgery 、 Publication bias 、 Meta-analysis 、 Medicine 、 Stromal cell 、 Proportional hazards model 、 Odds ratio 、 Internal medicine 、 Subgroup analysis 、 Gastroenterology 、 Adjuvant
摘要: The impact and management of microscopically positive margins in gastrointestinal stromal tumors (GISTs) remain unclear. aim this study is to estimate the prognostic value surgical for disease-free survival (DFS) overall (OS) patients with primary GISTs. Twelve studies 1985 GIST were included. recurrence rate R1 resection R0 group was 0.364 (95% CI 0.299–0.429) 0.296 0.161–0.430), respectively. Meta-analysis confirmed that a margin could significantly (HR 1.596, 95% 1.128–2.258; I2 = 37.5%, P value = 0.091), but had no influence on 1.430, 0.608–3.363; I2 = 60.8%, value = 0.013). Importantly, subgroup analysis revealed adjuvant imatinib treatment attenuate risk who received resection. 1.308, 0.583–2.935; I2 = 53.2%, value = 0.074). level evidence achieved “moderate” DFS “low” OS. In conclusion, an unfavorable factor proved be effective.
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