Red blood cells: Supercarriers for drugs, biologicals, and nanoparticles and inspiration for advanced delivery systems.

摘要: Red blood cells (RBCs) constitute a unique drug delivery system as biologic or hybrid carrier capable of greatly enhancing pharmacokinetics, altering pharmacodynamics (for example, by changing margination within the intravascular space), and modulating immune responses to appended cargoes. Strategies for RBC systems include internal surface loading, latter can be performed both ex vivo in vivo. A relatively new avenue is their application nanoparticles. Efforts are also being made incorporate features RBCs nanocarriers mimic most useful aspects, such long circulation stealth features. have recently been explored carriers antigens modulation response. Therefore, RBC-based represent supercarriers diverse array biomedical interventions, this reflected several industrial academic efforts that poised enter clinical realm.