Diversion of the Arbuzov reaction: alkylation of C–Cl instead of phosphonic ester formation on the fullerene cage
作者： Ol'ga A. Kraevaya , Alexander S. Peregudov , Sergey I. Troyanov , Ivan Godovikov , Natalya E. Fedorova
DOI: 10.1039/C9OB00593E
关键词: Human immunodeficiency virus (HIV) 、 Fullerene derivatives 、 Combinatorial chemistry 、 Alkylation 、 Fullerene 、 Chemistry
摘要: We report an “inversed” Arbuzov reaction of the fullerene derivatives C60Ar5Cl with trialkyl phosphites P(OR)3 producing alkylated C60Ar5R (R = Me, Et, iPr, nBu) almost quantitative yields. This provides a convenient synthetic route for preparation large variety functionalized tailored properties, e.g. water-soluble compounds demonstrating promising antiviral activities against HCMV, HSV1, HIV and several influenza virus strains.
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