Preoperative dexamethasone improves surgical outcome after laparoscopic cholecystectomy: a randomized double-blind placebo-controlled trial.

摘要: OBJECTIVE To determine the effects of preoperative dexamethasone on surgical outcome after laparoscopic cholecystectomy (LC). SUMMARY BACKGROUND DATA Pain and fatigue are dominating symptoms LC may prolong convalescence. METHODS In a double-blind, placebo-controlled study, 88 patients were randomized to intravenous (8 mg) or placebo 90 minutes before LC. Patients received similar standardized anesthetic, surgical, multimodal analgesic treatment. All recommended 2 days postoperative duration The primary endpoints pain. Preoperatively at several times during first 24 hours, we measured C-reactive protein (CRP) pulmonary function, pain scores, nausea, number vomiting episodes registered. Analgesic antiemetic requirements recorded. Also, daily basis, reported scores week dates for resumption work recreational activities. RESULTS Eight excluded from leaving 40 in each study group analysis. There no apparent side drug. Dexamethasone significantly reduced levels CRP (P = 0.01), overall pain, incisional hours < 0.05) total opioids 0.05). addition, cumulated visceral also nausea day operation Resumption activities was faster versus (median 1 days) CONCLUSION Preoperative fatigue, vomiting, convalescence undergoing noncomplicated LC, when compared with placebo, is routine use.