Tremor arrest with thalamic microinjections of muscimol in patients with essential tremor.
作者： Peter A. Pahapill , Ron Levy , Jonathan O. Dostrovsky , Karen D. Davis , Ali R. Rezai
DOI: 10.1002/1531-8249(199908)46:2<249::AID-ANA15>3.0.CO;2-C
关键词: Neurological disorder 、 Anesthesia 、 Essential tremor 、 Agonist 、 Electromyography 、 Thalamus 、 Muscimol 、 Microstimulation 、 Microinjections 、 Medicine
摘要: Six patients undergoing stereotactic procedures for essential tremor received microinjections of muscimol (a gamma-aminobutyric acid-A [GABA(A)] agonist) into the ventralis intermedius thalamus in areas where tremor-synchronous cells were identified electrophysiologically with microelectrode recordings and reduction occurred electrical microstimulation. Injections but not saline consistently reduced each patient. The effect had a mean latency 7 minutes lasted an average 9 minutes. We propose that GABA-mediated thalamic neuronal inhibition may represent mechanism underlying effectiveness surgery GABA analogues could potentially be used therapeutically.
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