Experimental Yersinia pestis infection in rodents after intragastric inoculation and ingestion of bacteria.

摘要: To clarify the pathogenesis of oral plague infection, we studied susceptibility three species rodents to intragastric inoculation Yersinia pestis, described pathology and progression measured antibody responses fraction IA antigen Y. pestis. The 50% lethal doses bacteria by for Mus musculus, Zygodontomys pixuna, Rattus rattus were log10 = 6.32, 5.46, 9.62, respectively, which at least 1,000-fold higher than values obtained subcutaneous inoculation. M. musculus was shown be susceptible infection also when ingested in drinking water. Microscopic consistent with heavy systemic infection. Quantitative cultures tissues different times after revealed that infections blood, liver, spleen preceded Peyer9s patches mesenteric lymph nodes. Stool negative. strain pestis used killed exposed a buffered solution pH less or equal 3. Antibody observed some surviving challenge. These results showed an effective pathogen produced fatal self-limited immunity but did not produce enteric lead fecal excretion bacteria. Images