A controlled study of penicillin prophylaxis against streptococcal impetigo.

摘要: By a double-blind cross-over design, prophylaxis of streptococcal skin disease by long-acting benzathine penicillin was studied in 78 children from 18 families with history experience this problem. The prevalence and the incidence lesions were significantly reduced during six-week follow-up period after therapy. duration protection variable, but majority protected for at least four weeks. Less observed younger children, due to either age- or dose-related factors. Skin more prevalent irrespective type injection given. Group A streptococci frequently recovered normal than administration. No indirect that might have been conferred other family members who received who, because allergy, no injections. Ninetyfive percent isolates M-typable, differences noted distribution specific serotypes various body sites.