DNA Mismatch Repair in Tumor Suppression
作者： Liya Gu , Guo-Min Li , Scott McCulloch
DOI: 10.1007/978-1-59259-230-2_9
关键词: DNA replication 、 Mutation 、 Biology 、 Mutagenesis 、 Genetics 、 DNA damage 、 Base pair 、 Microsatellite instability 、 DNA mismatch repair 、 Cancer
摘要: It is believed that cancer caused by mutations (1). In addition to the induced DNA damage, can arise from mismatched base pairs (bps) generated during replication and recombination. However, avoid mutagenesis, cells possess mutation avoidance systems, one of which mismatch repair (MMR) pathway. MMR primary cellular pathway responsible for correcting mispairs normal metabolism. bacteria, importance in maintaining genomic stability was demonstrated with observation, made more than 25 years ago, defects this lead elevated spontaneous mutability (2, 3). Inactivation eukaryotic results a mutator phenotype, thus also crucial eukaryotes. A dramatic example fact direct association deficiency human hereditary sporadic cancer.
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