Platelet serotonin measures in adolescents with conduct disorder
作者： Alan S. Unis , Edwin H. Cook , Jennifer G. Vincent , Diane K. Gjerde , Bruce D. Perry
DOI: 10.1016/S0006-3223(96)00465-9
关键词: Social skills 、 Psychiatry 、 Standardized test 、 Juvenile delinquency 、 Aggression 、 Impulsivity 、 Conduct disorder 、 Serotonergic 、 Whole blood 、 Psychology
摘要: Dysregulation of serotonergic function has been associated with aggression in several studies involving children, adolescents, and adults. This study investigated the relationship platelet measures to conduct disorder type, severity aggression, social skills impairment. Standardized assessments diagnosis, impulsivity, were obtained from 43 male adolescents (ages 13–17) incarcerated at an involuntary residential treatment facility for juvenile offenders. Blood samples collected assayed whole blood serotonin (5-HT) [ 3 H]-paroxetine-labeled 5-HT-transporter binding. Whole 5-HT was higher disorder, childhood type than subjects adolescent type. positively correlated violence rating current offense total points, staff ratings Our findings are consistent a between dysregulation aggressive behavior boys particularly onset.
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sci-hub.se 参考文章(36)
H. Brunner, M Nelen, X. Breakefield, H. Ropers, B. van Oost, Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A Science. ,vol. 262, pp. 578- 580 ,(1993) , 10.1126/SCIENCE.8211186
George M. Anderson, Daniel X. Freedman, Donald J. Cohen, Fred R. Volkmar, E. Lawrence Hoder, Peter McPhedran, Ruud B. Minderaa, Carl R. Hansen, J. Gerald Young, WHOLE BLOOD SEROTONIN IN AUTISTIC AND NORMAL SUBJECTS Journal of Child Psychology and Psychiatry. ,vol. 28, pp. 885- 900 ,(1987) , 10.1111/J.1469-7610.1987.TB00677.X
ZILA WELNER, WENDY REICH, BARBARA HERJANIC, KENNETH G. JUNG, HENRY AMADO, Reliability, validity, and parent-child agreement studies of the Diagnostic Interview for Children and Adolescents (DICA). Journal of the American Academy of Child and Adolescent Psychiatry. ,vol. 26, pp. 649- 653 ,(1987) , 10.1097/00004583-198709000-00007
Janet B. W. Williams, Michael First, Diagnostic and Statistical Manual of Mental Disorders Encyclopedia of Social Work. ,(2013) , 10.1093/ACREFORE/9780199975839.013.104
Rolf Loeber, Natural Histories of Conduct Problems, Delinquency, and Associated Substance Use Advances in clinical child psychology. ,vol. 11, pp. 73- 124 ,(1988) , 10.1007/978-1-4613-9829-5_2
Kovacs M, The Children's Depression, Inventory (CDI). Psychopharmacology Bulletin. ,vol. 21, pp. 995- 998 ,(1985)
Howard E. Freeman, Lee N. Robins, Deviant Children Grown Up. American Sociological Review. ,vol. 32, pp. 149- ,(1967) , 10.2307/2091752
PT Mehlman, JD Higley, I Faucher, AA Lilly, DM Taub, J Vickers, SJ Suomi, M Linnoila, Correlation of CSF 5-HIAA concentration with sociality and the timing of emigration in free-ranging primates. American Journal of Psychiatry. ,vol. 152, pp. 907- 913 ,(1995) , 10.1176/AJP.152.6.907
Alan E. Kazdin, Benjamin B. Lahey, Advances in Clinical Child Psychology ,(1989)
M. R. Nelen, H. G. Brunner, P. Van Zandvoort, E. C. Wolters, M. A. Kuiper, H. H. Ropers, N. G. G. M. Abeling, B. A. Van Oost, A. H. Van Gennip, X-linked borderline mental retardation with prominent behavioral disturbance: phenotype, genetic localization, and evidence for disturbed monoamine metabolism. American Journal of Human Genetics. ,vol. 52, pp. 1032- 1039 ,(1993)