The application of in vitro‐derived human neurons in neurodegenerative disease modeling

作者: Gary X. D'Souza , Shannon E. Rose , Allison Knupp , Daniel A. Nicholson , Christopher Dirk Keene

DOI: 10.1002/JNR.24615

关键词: Small animalScientific fieldDisease mechanismsNeuroscienceInduced pluripotent stem cellBiologyStem cellHuman brainReprogrammingDisease

摘要: The development of safe and effective treatments for age‐associated neurodegenerative disorders is an on‐going challenge faced by the scientific field. Key to the development of such …

参考文章(122)
Xiao-Jiang Li, Shihua Li, Large Animal Models of Huntington's Disease. Current topics in behavioral neurosciences. ,vol. 22, pp. 149- 160 ,(2013) , 10.1007/7854_2013_246
Eleonora Passeri, Ashley M. Wilson, Amedeo Primerano, Mari A. Kondo, Srona Sengupta, Rupali Srivastava, Minori Koga, Cassandra Obie, Peter P. Zandi, Fernando S. Goes, David Valle, Judith L. Rapoport, Akira Sawa, Shin-ichi Kano, Koko Ishizuka, Enhanced conversion of induced neuronal cells (iN cells) from human fibroblasts: Utility in uncovering cellular deficits in mental illness-associated chromosomal abnormalities. Neuroscience Research. ,vol. 101, pp. 57- 61 ,(2015) , 10.1016/J.NEURES.2015.07.011
Sandra Siegert, Jinsoo Seo, Ester J Kwon, Andrii Rudenko, Sukhee Cho, Wenyuan Wang, Zachary Flood, Anthony J Martorell, Maria Ericsson, Alison E Mungenast, Li-Huei Tsai, The schizophrenia risk gene product miR-137 alters presynaptic plasticity Nature Neuroscience. ,vol. 18, pp. 1008- 1016 ,(2015) , 10.1038/NN.4023
Jerome Mertens, Apuã CM Paquola, Manching Ku, Emily Hatch, Lena Böhnke, Shauheen Ladjevardi, Sean McGrath, Benjamin Campbell, Hyungjun Lee, Joseph R Herdy, J Tiago Gonçalves, Tomohisa Toda, Yongsung Kim, Jürgen Winkler, Jun Yao, Martin W Hetzer, Fred H Gage, None, Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects Cell Stem Cell. ,vol. 17, pp. 705- 718 ,(2015) , 10.1016/J.STEM.2015.09.001
Young Hye Kim, Se Hoon Choi, Carla D'Avanzo, Matthias Hebisch, Christopher Sliwinski, Enjana Bylykbashi, Kevin J Washicosky, Justin B Klee, Oliver Brüstle, Rudolph E Tanzi, Doo Yeon Kim, A 3D human neural cell culture system for modeling Alzheimer's disease Nature Protocols. ,vol. 10, pp. 985- 1006 ,(2015) , 10.1038/NPROT.2015.065
Lorenz Studer, Elsa Vera, Daniela Cornacchia, Programming and Reprogramming Cellular Age in the Era of Induced Pluripotency. Cell Stem Cell. ,vol. 16, pp. 591- 600 ,(2015) , 10.1016/J.STEM.2015.05.004
Wenxiang Hu, Binlong Qiu, Wuqiang Guan, Qinying Wang, Min Wang, Wei Li, Longfei Gao, Lu Shen, Yin Huang, Gangcai Xie, Hanzhi Zhao, Ying Jin, Beisha Tang, Yongchun Yu, Jian Zhao, Gang Pei, None, Direct Conversion of Normal and Alzheimer’s Disease Human Fibroblasts into Neuronal Cells by Small Molecules Cell Stem Cell. ,vol. 17, pp. 204- 212 ,(2015) , 10.1016/J.STEM.2015.07.006
Sandra Rodríguez-Rodero, Juan Luis Fernández-Morera, Edelmiro Menéndez-Torre, Vincenzo Calvanese, Agustín F Fernández, Mario F Fraga, None, Aging genetics and aging. Aging and Disease. ,vol. 2, pp. 186- 195 ,(2011)
Andrew S. Yoo, Alfred X. Sun, Li Li, Aleksandr Shcheglovitov, Thomas Portmann, Yulong Li, Chris Lee-Messer, Ricardo E. Dolmetsch, Richard W. Tsien, Gerald R. Crabtree, MicroRNA-mediated conversion of human fibroblasts to neurons Nature. ,vol. 476, pp. 228- 231 ,(2011) , 10.1038/NATURE10323
Michael W. Nestor, Samson Jacob, Bruce Sun, Deborah Prè, Andrew A. Sproul, Seong Im Hong, Chris Woodard, Matthew Zimmer, Vorapin Chinchalongporn, Ottavio Arancio, Scott A. Noggle, Characterization of a subpopulation of developing cortical interneurons from human iPSCs within serum-free embryoid bodies American Journal of Physiology-cell Physiology. ,vol. 308, ,(2015) , 10.1152/AJPCELL.00263.2014