Skeletal muscle fiber type conversion during the repair of mouse soleus: potential implications for muscle healing after injury.
作者： Tetsuya Matsuura , Yong Li , Jean-Paul Giacobino , Freddie H. Fu , Johnny Huard
DOI: 10.1002/JOR.20451
关键词: Myosin 、 Myocyte 、 Cytoplasm 、 Cardiotoxin 、 Wound healing 、 Anatomy 、 Biology 、 Skeletal muscle 、 Blot 、 Regeneration (biology) 、 Cell biology
摘要: We used a mouse model of cardiotoxin injury to examine fiber type conversion during muscle repair. evaluated the soleus muscles 37 wild-type mice at 2, 4, 8, and 12 weeks after injury. also antibodies (fMHC sMHC) against fast slow myosin heavy chain classify myofibers into three categories: fast-, slow-, mixed (hybrid)-type (myofibers expressing both fMHC sMHC). Our results revealed an increase in percentage slow-type decrease fast-type repair process. The hybrid-type increased 2 injury, then gradually decreased over following 6 weeks. Similarly, our analysis centronucleated showed decreases percentages fast- myofibers. investigated relationship between myofiber peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha). expression PGC-1alpha protein, which is expressed nucleus cytoplasm regenerating myofibers, sMHC protein with time injection, but we observed no significant differential fibers PGC-1alpha-positive underwent These suggest that contributes this phenomenon could influence recovery injured muscle.
sci-hub.se 参考文章(26)
Thomas M. Best, Kam D. Hunter, Muscle injury and repair. Physical Medicine and Rehabilitation Clinics of North America. ,vol. 11, pp. 251- 266 ,(2000) , 10.1016/S1047-9651(18)30128-1
Joseph P Ramos, Suturing Versus Immobilization of a Muscle Laceration A Morphological and Functional Study in a Mouse Model American Journal of Sports Medicine. ,vol. 27, pp. 222- 229 ,(1999) , 10.1016/S0196-0644(99)80077-8
Martin W. Berchtold, Heinrich Brinkmeier, Markus Müntener, Calcium Ion in Skeletal Muscle: Its Crucial Role for Muscle Function, Plasticity, and Disease Physiological Reviews. ,vol. 80, pp. 1215- 1265 ,(2000) , 10.1152/PHYSREV.2000.80.3.1215
G.C. Farnbach, M.J. Brown, R.L. Barchi, A maturational defect in passive membrane properties of dystrophic mouse muscle. Experimental Neurology. ,vol. 62, pp. 539- 554 ,(1978) , 10.1016/0014-4886(78)90267-4
D.H. Jack, The orientation relationships of interstitial phases in iron Materials Science and Engineering. ,vol. 13, pp. 19- 27 ,(1974) , 10.1016/0025-5416(74)90017-2
Zhidan Wu, Pere Puigserver, Ulf Andersson, Chenyu Zhang, Guillaume Adelmant, Vamsi Mootha, Amy Troy, Saverio Cinti, Bradford Lowell, Richard C. Scarpulla, Bruce M. Spiegelman, Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1 Cell. ,vol. 98, pp. 115- 124 ,(1999) , 10.1016/S0092-8674(00)80611-X
M. G. Havenith, R. Visser, J. M. C. Schrijvers-van Schendel, F. T. Bosman, Muscle fiber typing in routinely processed skeletal muscle with monoclonal antibodies. Histochemistry and Cell Biology. ,vol. 93, pp. 497- 499 ,(1990) , 10.1007/BF00266407
William E. Garrett, Anthony V. Seaber, Jane Boswick, James R. Urbaniak, J. Leonard Goldner, Recovery of skeletal muscle after laceration and repair Journal of Hand Surgery (European Volume). ,vol. 9, pp. 683- 692 ,(1984) , 10.1016/S0363-5023(84)80014-3
TIMO HURME, HANNU KALIMO, MATTI LEHTO, MARKKU J??RVINEN, Healing of skeletal muscle injury: an ultrastructural and immunohistochemical study. Medicine and Science in Sports and Exercise. ,vol. 23, pp. 801- 810 ,(1991) , 10.1249/00005768-199107000-00006
Jonathan C. Jarvis, Thomas Mokrusch, Martin M.N. Kwende, Hazel Sutherland, Stanley Salmons, Fast-to-slow transformation in stimulated rat muscle. Muscle & Nerve. ,vol. 19, pp. 1469- 1475 ,(1996) , 10.1002/(SICI)1097-4598(199611)19:11<1469::AID-MUS11>3.0.CO;2-O