Pathophysiology of nasal obstruction and meta-analysis of early and late effects of levocetirizine.

摘要: Nasal obstruction, also referred to as congestion, blockage or stuffiness, is a crucial symptom in allergic rhinitis (AR) and may affect sleep well quality of life. Early- late-phase-allergic reactions both contribute nasal although it primarily represents major the chronic reaction. A complex network inflammatory neurogenic phenomena relates including subepithelial accumulation cells, particularly mast cells eosinophils, release neuropeptides. obstruction difficult-to-treat symptom. Vasoconstrictors (decongestants) intranasal corticosteroids, due their anti-inflammatory properties, have mainly been used for relieving passages from congested mucosa. However, there accumulating evidence recently that latest-generation potent antihistamines decongestant properties AR. This paper aims review pathophysiologic background an antihistamine, levocetirizine, congestion. meta-analysis on early late effects levocetirizine under artificial natural allergen exposure conditions presented, demonstrating convincingly shows consistent effect over first 2 h sustained 6 weeks.