Synthetic hydrogels with stiffness gradients for durotaxis study and tissue engineering scaffolds
作者： Minji Whang , Jungwook Kim
DOI: 10.1007/S13770-016-0026-X
关键词: Cell migration 、 Regeneration (biology) 、 Design elements and principles 、 Biomedical engineering 、 Scaffold 、 Stiffness 、 Tissue engineering 、 Self-healing hydrogels 、 Materials science 、 Durotaxis
摘要: Migration of cells along the right direction is of paramount importance in a number of in vivo circumstances such as immune response, embryonic developments, morphogenesis, and healing of wounds and scars. While it has been known for a while that spatial gradients in chemical cues guide the direction of cell migration, the significance of the gradient in mechanical cues, such as stiffness of extracellular matrices (ECMs), in directed migration of cells has only recently emerged. With advances in synthetic chemistry, micro-fabrication …
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