Single dose oral gabapentin for established acute postoperative pain in adults

摘要: Background Gabapentin is an antiepileptic drug, also used in the treatment of neuropathic pain, which subject a Cochrane review, currently under revision. Its efficacy treating established acute postoperative pain has not been demonstrated. Objectives To assess and safety single dose oral gabapentin compared with placebo using methods that permit comparison other analgesics. Search methods We searched CENTRAL, MEDLINE, EMBASE, Oxford Pain Relief Database. Additional studies were sought from reference lists retrieved articles reviews. Clinical trials databases for unpublished studies; clinical trial reports several have made public following litigation US. Selection criteria Single dose, randomised, double-blind, placebo-controlled relief moderate to severe adults. Data collection analysis Studies assessed methodological quality data extracted by two review authors independently. Numbers participants at least 50% maximum possible total (TOTPAR) or summed intensity difference (SPID) calculated derive relative benefit (RB) risk (RR), number-needed-to-treat-to-benefit (NNT). rescue medication, time its use, as additional measures efficacy. Information on adverse events withdrawals was collected. Main results Four met inclusion criteria; three, had dental surgery, one followed major orthopaedic surgery; 177 treated 250 mg, 21 500 172 placebo. At over 6 hours achieved 15% mg 5% placebo; giving RB 2.5 (95% CI 1.2 5.0) NNT 11 (6.4 35). Significantly fewer needed medication within than prevent use 5.8. About third reported both No serious occurred gabapentin. Authors' conclusions Gabapentin statistically superior but limited value inferior commonly analgesics. Gabapentin clinically useful stand-alone analgesic though this probably first demonstration effect pain.