Identification of a transmission chain of HIV type 1 containing drug resistance-associated mutations.
作者： Stephen Taylor , Patricia Cane , Stéphane Hué , Li Xu , Terri Wrin
DOI: 10.1089/088922203765551700
关键词: Immunology 、 Virology 、 Biology 、 Virus 、 Reverse transcriptase 、 Mutation 、 Drug resistance 、 Lentivirus 、 Genotype 、 Viral disease 、 Sexual transmission
摘要: We have investigated a potential transmission chain of HIV-1 with drug resistance-associated mutations between three individuals over period 5 years by use cloning and sequencing viral genes, phenotypic characterization. Viruses containing reverse transcriptase were transmitted sequentially homosexual men (A, B, C), persisted in one individual for at least 4 years, despite intermittent therapy reduced replicative capacity compared wild-type strains. Clonal analysis the envelope gene from semen blood virus showed that to patient C was more closely related than B. Our data suggest HIV variants can persist following primary infection, intervening antiretroviral therapy, subsequently sexually transmitted. provide "proof principle" such therefore become "fixed" within...
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