The alpha4bbeta7-integrin is dynamically expressed on murine eosinophils and involved in eosinophil trafficking to the intestine.

摘要: BACKGROUND Of the numerous adhesion molecules expressed by eosinophils, alpha4-integrin has been identified as critically involved in eosinophil trafficking lung. Most studies have focused on role of alpha4beta1-adhesion complex, but eosinophils also express alpha4beta7-integrin complex. OBJECTIVE To investigate alpha4beta7, assessing its membrane expression from different compartments using allergen-challenged mice and IL-4/IL-5 bi-transgenic mice. In addition, we aim to determine impact beta7-integrin deficiency recruitment lungs intestine specific experimental allergic models. RESULTS Evaluation alpha4beta7 bronchoalveolar lavage fluid (BALF) lung tissue revealed a down-regulation this integrin migrate through lungs. Indeed isolated BALF had low alpha4beta7-complex. While alpha4-chain remained unchanged, significant decrease beta7-surface was observed. Intestinal Peyer's patches, displayed alpha4beta7-integrin, albeit only modest. contrast, circulating blood spleen, high levels alpha4beta7-integrin. However, into beta7-integrin-deficient not significantly impaired response respiratory allergen challenges. beta7-deficient intestine. CONCLUSION Taken together, these results identify differential critical regulating responses