作者: Maik Weidauer , Elisabeth Irran , Stephan Enthaler
DOI: 10.1016/J.INOCHE.2015.01.028
关键词: Salt (chemistry) 、 Metathesis 、 Chemistry 、 Boronic acid 、 Catalysis 、 Reagent 、 Mannich reaction 、 Medicinal chemistry 、 Deprotonation 、 Coupling reaction 、 Organic chemistry
摘要: Abstract A new synthetic route to the trispyrrole iron(II) complex {K(dme) 4 [tpa Mes Fe]} was established starting from BOC-protected pyrrol via synthesis of corresponding boronic acid, cross-coupling reaction, deprotection, triple Mannich a deprotonation and finally salt metathesis. The characterized applied in iron-catalyzed coupling reactions. In more detail, with catalytic amounts K(dme) Fe] homo-coupling aromatic Grignard reagents as well hetero-coupling were feasible. Noteworthy, force reaction nitrous oxide added realize yields up 93% at mild conditions.