Analysis of correlations between selected endothelial cell activation markers, disease activity, and nailfold capillaroscopy microvascular changes in systemic lupus erythematosus patients
作者： Mariusz Ciołkiewicz , Anna Kuryliszyn-Moskal , Piotr Adrian Klimiuk
DOI: 10.1007/S10067-009-1308-7
关键词: Endothelial stem cell 、 Vascular endothelial growth factor 、 Pathology 、 Lupus erythematosus 、 Medicine 、 Rheumatology 、 Neovascularization 、 Microcirculation 、 Endothelium 、 Pathogenesis 、 Internal medicine
摘要: The aim of the study was to evaluate correlation between selected serum endothelial cell activation markers such as vascular growth factor (VEGF), endothelin-1 (ET-1), soluble thrombomodulin (sTM), E-selectin (sE-selectin), disease activity, and microvascular changes determined by nailfold capillaroscopy in patients with systemic lupus erythematosus (SLE). Serum levels VEGF, ET-1, sTM, sE-selectin were an enzyme-linked immunosorbent assay 80 SLE patients. activity measured Systemic Lupus Erythematosus Disease Activity Index score. Nailfold performed all Positive found VEGF both ET-1 (r = 0.294, p < 0.01) 0.274, 0.05) well sTM 0.273, concentrations. We noticed also positive 0.224, 0.471, 0.001) concentration grade morphological observed 0.458, 0.001). There capillaroscopic score 0.339, 0.01). Our data suggest that concentrations may reflect their participation pathogenesis SLE. seems microcirculation course SLE, visualised capillaroscopy. relationship capillaroscopy, markers, clinical points important role abnormalities manifestation disease.
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