[Ca2+]i as a potential downregulator of α2β1-integrin-mediated A2058 tumor cell migration to type IV collagen

作者: Louis Hodgson , Cheng Dong

DOI: 10.1152/AJPCELL.2001.281.1.C106

关键词: Cell cultureSignal transductionCell biologyCollagen receptorMelanomaIntegrinChemotaxisType IV collagenCell chemotaxisBiology

摘要: We have investigated cellular Ca2+ regulation during A2058 human melanoma cell chemotaxis to type IV collagen (CIV). identified α2β1-integrin as the primary mediator of response ...

参考文章(40)
Joseph P.Y. Kao, Practical aspects of measuring [Ca2+] with fluorescent indicators. Methods in Cell Biology. ,vol. 40, pp. 155- 181 ,(1994) , 10.1016/S0091-679X(08)61114-0
Donald M. Bers, Chris W. Patton, Richard Nuccitelli, A practical guide to the preparation of Ca2+ buffers. Methods in Cell Biology. ,vol. 99, pp. 1- 26 ,(2010) , 10.1016/B978-0-12-374841-6.00001-3
S. K. Masur, K. Michelson, Liang-Xi Zhu, J. Weissberg, S. Antohi, A. Idris, Integrin-dependent tyrosine phosphorylation in corneal fibroblasts. Investigative Ophthalmology & Visual Science. ,vol. 36, pp. 1837- 1846 ,(1995)
M. A. Schwartz, D. Toksoz, R. Khosravi-Far, Transformation by Rho exchange factor oncogenes is mediated by activation of an integrin‐dependent pathway. The EMBO Journal. ,vol. 15, pp. 6525- 6530 ,(1996) , 10.1002/J.1460-2075.1996.TB01043.X
D.M. Savarese, J.T. Russell, A Fatatis, L.A. Liotta, Type IV collagen stimulates an increase in intracellular calcium. Potential role in tumor cell motility. Journal of Biological Chemistry. ,vol. 267, pp. 21928- 21935 ,(1992) , 10.1016/S0021-9258(19)36702-X
Laurence A. Boxer, Suzanne J. Suchard, Rosemarie Fernandez, Beta2 integrins are not required for tyrosine phosphorylation of paxillin in human neutrophils. Journal of Immunology. ,vol. 159, pp. 5568- 5575 ,(1997)
J. Lotem, R. Kama, L. Sachs, Suppression or induction of apoptosis by opposing pathways downstream from calcium-activated calcineurin. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 96, pp. 12016- 12020 ,(1999) , 10.1073/PNAS.96.21.12016
P Vandenberg, A Kern, A Ries, L Luckenbill-Edds, K Mann, K Kühn, Characterization of a type IV collagen major cell binding site with affinity to the alpha 1 beta 1 and the alpha 2 beta 1 integrins. Journal of Cell Biology. ,vol. 113, pp. 1475- 1483 ,(1991) , 10.1083/JCB.113.6.1475