Follow-up evaluation of oculomotor performance with fMRI in the subacute phase of concussion

作者: Brian Johnson , Mark Hallett , Semyon Slobounov

DOI: 10.1212/WNL.0000000000001968

关键词: NeuroimagingSaccadeAsymptomaticMagnetic resonance imagingFunctional neuroimagingEye movementConcussionPsychologyPhysical medicine and rehabilitationYoung adult

摘要: Objective: To expand on our previous study by performing a follow-up testing session in the subacute phase of injury for participants recently diagnosed with concussion. Methods: A battery oculomotor tests were administered to 30 days postconcussion while simultaneous fMRI was performed. Results: Three 7 tasks (antisaccade, self-paced saccade, and memory-guided saccade) showed significant differences between concussed group compared normal volunteers. However, performance these 3 did show improvement from acute injury. The analysis revealed brain activation patterns volunteers, still demonstrating increased larger areas activation. Similar performance, that at postinjury, more closely mirrored volunteer following insult. Conclusions: Even despite being clinically asymptomatic, advanced techniques are able detect subtle lingering alterations brain. Therefore, progressive neuroimaging such as conjunction assessment may be beneficial clinical management

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