Vergleichende Untersuchungen über die hypertensive Wirkung von Aldosteron und Desoxycorticosteron

摘要: In the adrenalectomized and unilaterally nephrectomized rat an investigation has been carried out on influence of a four weeks' treatment with aldosterone desoxycorticosterone-acetate in doses which are equieffective concerning sodium retaining capacity. Desoxycorticosterone-acetate produced hypertension, perivascular granuloma renal lesions, whereas under blood pressure remained normal no histopathological alterations could be found. Towards end experiment animals treated took up twice as much drinking fluid aldosterone. Although results obtained so far only preliminary character it is obvious that retention does not produce same side effects desoxycorticosterone-acetate.