Deldrin and parathion interaction in the prostate and liver of the mouse.
作者： Lonnie G. Schein , John A. Thomas
DOI: 10.1080/15287397609529382
关键词: Oral administration 、 Metabolism 、 Prostate 、 Testosterone 、 Endocrinology 、 Internal medicine 、 Dieldrin 、 Microsome 、 Androstenedione 、 Parathion 、 Chemistry
摘要: The oral administration of dieldrin (1.25 mg/kg daily × 5 or 10) and/or parathion (5.2, 2.6, 1.3 caused significant alterations in the metabolism [1,2‐3H] testosterone by anterior prostate gland and hepatic microsomal enzyme system mouse. A 5‐day treatment followed another with led to increases levels [3H] androstanediol androstenedione formed vitro. Dieldrin alone, plus parathion, reductions [3H]androstenedione enzymes. Concomitantly, were observed 7α‐and 6s‐testosterone hydroxylase activities animals treated administration. present findings revealed that leads changes male sex hormones mous...
sci-hub.se 参考文章(24)
E. C. Miller, J. A. Miller, A. H. Conney, The metabolism of methylated aminoazo dyes. V. Evidence for induction of enzyme synthesis in the rat by 3-methylcholanthrene. Cancer Research. ,vol. 16, pp. 450- 459 ,(1956)
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
A. H. Conney, PHARMACOLOGICAL IMPLICATIONS OF MICROSOMAL ENZYME INDUCTION Pharmacological Reviews. ,vol. 19, pp. 317- 366 ,(1967)
J STREET, Insecticide interactions affecting residue accumulation in animal tissues Toxicology and Applied Pharmacology. ,vol. 8, pp. 497- 504 ,(1966) , 10.1016/0041-008X(66)90060-3
H. E. Swann, G. S. Woodson, T. A. Ballard, The acute toxicity of intramuscular parathion in rats and the relation of weight, sex and sex hormones to this toxicity. American Industrial Hygiene Association Journal. ,vol. 19, pp. 190- 195 ,(1958) , 10.1080/00028895809343574
A. H. Conney, J. J. Burns, Metabolic interactions among environmental chemicals and drugs. Science. ,vol. 178, pp. 576- 586 ,(1972) , 10.1126/SCIENCE.178.4061.576
James T. Stevens, Robert E. Stitzel, Joseph J. McPhillips, The effects of subacute administration of anticholinesterase insecticides on hepatic microsomal metabolism Life Sciences. ,vol. 11, pp. 423- 431 ,(1972) , 10.1016/0024-3205(72)90250-0
Charles W. Dunnett, A Multiple Comparison Procedure for Comparing Several Treatments with a Control Journal of the American Statistical Association. ,vol. 50, pp. 1096- 1121 ,(1955) , 10.1080/01621459.1955.10501294
Lonnie G. Schein, John A. Thomas, Effects of dieldrin on the uptake and metabolism of testosterone-1,2-3H by rodent sex accessory organs. Environmental Research. ,vol. 9, pp. 26- 31 ,(1975) , 10.1016/0013-9351(75)90046-8
M.T. Smith, J.A. Thomas, C.G. Smith, M.G. Mawhinney, J.W. Lloyd, Effects of DDT on radioactive uptake from testosterone-1,2-3H by mouse prostate glands☆ Toxicology and Applied Pharmacology. ,vol. 23, pp. 159- 164 ,(1972) , 10.1016/0041-008X(72)90215-3