Long noncoding RNA MAFG-AS1 promotes proliferation, migration and invasion of hepatocellular carcinoma cells through downregulation of miR-6852.
作者： Hui Ouyang , Li Zhang , Zhen Xie , Simin Ma
关键词: Long non-coding RNA 、 Cell 、 Downregulation and upregulation 、 Gene knockdown 、 Biology 、 Oncogene 、 Molecular medicine 、 Cancer research 、 Cell cycle 、 Colorectal cancer
摘要: Long noncoding RNAs (lncRNAs) have been shown to participate in the development and progression of a number different types cancer, including hepatocellular carcinoma (HCC). A recent report has indicated that lncRNA MAFG-antisense 1 (AS1) promotes colorectal cancer. However, role MAFG-AS1 other cancer remains unclear. The aim present study was examine effect HCC. Based on Cancer Genome Atlas database reverse transcription-quantitative PCR results, it determined expression increased HCC tissues cell lines. Following knockdown MAFG-AS1, Cell Counting Kit-8 assay Transwell demonstrated proliferation, migration invasion lines were significantly inhibited. It additionally there negative regulatory association between miR-6852. Inhibition miR-6852 LncRNA promoted by dampening function may thus be novel target for treating patients with
sci-hub.se 参考文章(28)
Dragana Kopanja, Akshay Pandey, Megan Kiefer, Zebin Wang, Neha Chandan, Janai R. Carr, Roberta Franks, Dae-Yeul Yu, Grace Guzman, Ajay Maker, Pradip Raychaudhuri, Essential roles of FoxM1 in Ras-induced liver cancer progression and in cancer cells with stem cell features Journal of Hepatology. ,vol. 63, pp. 429- 436 ,(2015) , 10.1016/J.JHEP.2015.03.023
Ilchung Shin, Seonhoe Kim, Hyun Song, Hyeong-Reh Choi Kim, Aree Moon, H-Ras-specific Activation of Rac-MKK3/6-p38 Pathway Journal of Biological Chemistry. ,vol. 280, pp. 14675- 14683 ,(2005) , 10.1074/JBC.M411625200
Yanying Wang, Lei He, Ying Du, Pingping Zhu, Guanling Huang, Jianjun Luo, Xinlong Yan, Buqing Ye, Chong Li, Pengyan Xia, Geng Zhang, Yong Tian, Runsheng Chen, Zusen Fan, The Long Noncoding RNA lncTCF7 Promotes Self-Renewal of Human Liver Cancer Stem Cells through Activation of Wnt Signaling Cell Stem Cell. ,vol. 16, pp. 413- 425 ,(2015) , 10.1016/J.STEM.2015.03.003
Jiayi Wang, Xiangfan Liu, Huacheng Wu, Peihua Ni, Zhidong Gu, Yongxia Qiao, Ning Chen, Fenyong Sun, Qishi Fan, CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer Nucleic Acids Research. ,vol. 38, pp. 5366- 5383 ,(2010) , 10.1093/NAR/GKQ285
Jiayi Wang, Hongmei Wang, Yue Zhang, Ni Zhen, Li Zhang, Yongxia Qiao, Wenhao Weng, Xiangfan Liu, Lifang Ma, Weifan Xiao, Wenjun Yu, Qinghua Chu, Qiuhui Pan, Fenyong Sun, Mutual inhibition between YAP and SRSF1 maintains long non-coding RNA, Malat1-induced tumourigenesis in liver cancer. Cellular Signalling. ,vol. 26, pp. 1048- 1059 ,(2014) , 10.1016/J.CELLSIG.2014.01.022
Marco L Davila, Isabelle Riviere, Xiuyan Wang, Shirley Bartido, Jae Park, Kevin Curran, Stephen S Chung, Jolanta Stefanski, Oriana Borquez-Ojeda, Malgorzata Olszewska, Jinrong Qu, Teresa Wasielewska, Qing He, Mitsu Fink, Himaly Shinglot, Maher Youssif, Mark Satter, Yongzeng Wang, James Hosey, Hilda Quintanilla, Elizabeth Halton, Yvette Bernal, Diana CG Bouhassira, Maria E Arcila, Mithat Gonen, Gail J Roboz, Peter Maslak, Dan Douer, Mark G Frattini, Sergio Giralt, Michel Sadelain, Renier Brentjens, Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia Science Translational Medicine. ,vol. 6, ,(2014) , 10.1126/SCITRANSLMED.3008226
Kenneth J. Livak, Thomas D. Schmittgen, ANALYSIS OF RELATIVE GENE EXPRESSION DATA USING REAL-TIME QUANTITATIVE PCR AND THE 2(-DELTA DELTA C(T)) METHOD Methods. ,vol. 25, pp. 402- 408 ,(2001) , 10.1006/METH.2001.1262
BYUNG SOH MIN, NAM KYU KIM, HEE CHUL JEONG, HYUN CHEOL CHUNG, High levels of serum VEGF and TIMP-1 are correlated with colon cancer liver metastasis and intrahepatic recurrence after liver resection Oncology Letters. ,vol. 4, pp. 123- 130 ,(2012) , 10.3892/OL.2012.691
Muhammet Akyuz, Pinar Yazici, Hakan Yigitbas, Cem Dural, Alexis Okoh, Shamil Aliyev, Federico Aucejo, Cristiano Quintini, John Fung, Eren Berber, Oncologic results of laparoscopic liver resection for malignant liver tumors. Journal of Surgical Oncology. ,vol. 113, pp. 127- 129 ,(2016) , 10.1002/JSO.24119
Huilong Duan, Zhenzhen Huang, Haomin Li, TCGA4U: A Web-Based Genomic Analysis Platform To Explore And Mine TCGA Genomic Data For Translational Research. Studies in health technology and informatics. ,vol. 216, pp. 658- 662 ,(2015) , 10.3233/978-1-61499-564-7-658