Gamma-carboxyglutamate in a neuroactive toxin.
作者： J M McIntosh , B M Olivera , L J Cruz , W R Gray
DOI: 10.1016/S0021-9258(17)42601-9
关键词: Conus marmoreus 、 Peptide sequence 、 Conus textile 、 Biology 、 Amino acid 、 Gamma carboxyglutamate 、 Conantokins 、 Conus geographus 、 Peptide 、 Biochemistry
摘要: Abstract The venom of a fish-hunting cone snail (Conus geographus) contains novel toxin, the "sleeper" peptide, which induces sleep-like state in mice when injected intracerebrally. We demonstrate that this peptide 5 mol gamma-carboxyglutamate (Gla) 17 amino acids. acid sequence sleeper is Gly-Glu-Gla-Gla-Leu-Gln-Gla-Asn-Gln-Gla-Leu-Ile-Arg-Gla-Lys-Ser-Asn-NH2.
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