Synthesis, Characterization, Drug Delivery, and Splinting Activity of Folic Acid Bridged Poly(ɛ-caprolactone-co-tetrahydrofuran)
作者： S. Kailash , B. Meenarathi , S. Palanikumar , R. Anbarasan
DOI: 10.1080/00914037.2014.996711
关键词: Comonomer 、 Polymer 、 Phthalic anhydride 、 Molar mass distribution 、 Drug delivery 、 Tetrahydrofuran 、 Copolymer 、 Polymer chemistry 、 Materials science 、 Ring-opening polymerization
摘要: Synthesis of a material for drug delivery application is fascinating field research. Folic acid (FA) an anticancer and used as initiator the ring opening polymerization ϵ-caprolactone (CL) at 160°C 2 h under N2 atmosphere. The FA end-capped PCL (P1) was effective tetrahydrofuran (THF) in presence phthalic anhydride (PAH) comonomer (P2) 45°C 48 h inert atmospheric condition with mild stirring. obtained polymers were characterized by FTIR, NMR, DSC, TGA, FESEM, GPC, SEM, UV-visible spectrometry, EDAX. Appearance peak 1595 cm−1 confirmed formation copolymer through tetrahydrofuronium ion. structure can be noting 7.6 ppm 1H-NMR spectrum. increase weight average molecular P2 formation. previously synthesized polymer tested toward splitting further det...
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