Structures of Integrin Domains and Concerted Conformational Changes in the Bidirectional Signaling Mechanism of αIIbβ3

摘要: Integrins are heterodimeric type I transmembrane cell-adhesive receptors whose affinity for ligands is regulated by tertiary and quaternary conformational changes that transmitted from the cytoplasmic tails to extracellular ectodomains during transition inactive active state. Receptor occupancy initiates further structural alterations transduce signals across plasma membrane result in receptor clustering recruitment of signaling molecules cytoskeletal rearrangements at integrin's domains. The large distance between intracellular domains ligand-binding site, which an extended conformation spans more 200 A, imposes a complex mechanism interdomain communication bidirectional information flow membrane. Significant progress has recently been made elucidating crystal electron microscopy structures integrin its unliganded liganded states, nuclear m...