High-throughput on-chip DNA fragmentation
作者： Lingling Shui , Edwin Carlen , Mingliang Jin , Johan G. Bomer , Albert van den Berg
DOI:
关键词: Biophysics 、 Nanotechnology 、 Materials science 、 Throughput (business) 、 genomic DNA 、 Fragmentation (cell biology) 、 Microfluidics 、 DNA 、 Chip 、 DNA fragmentation 、 Length distribution
摘要: free microfluidic deoxyribonucleic acid (DNA) fragmentation chip that is based on hydrodynamic shearing. Genomic DNA has been reproducibly fragmented with 2-10 kbp fragment lengths by applying hydraulic pressure ΔP across micromachined constrictions in the channels. The utilization of a series reduces variance length distribution; and parallel channels design eliminates device clogging.
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