Exploring the Utility of Carbohydrate Associated Transferase Activities as Potential Tumor Markers for Human Gastric Cancer

摘要: Mucins are large, highly O-glycosylated proteins that present at the surface of most epithelial cells and involved in protection lubrication epithelium (Gendler Spicer 1995). The expression mucin genes is organ-and cell-type specific. increased altered glycosylation mucins influence cellular growth, differentiation, transformation, adhesion immune surveillance (Hollingworth swanson 2004) associated with development cancer. have been implicated biologic behavior progression several cancers. During carcinogenesis, aberrant leads to tumor subpopulations different properties (Taniguchi et al. 1996; Hiraiwa 1996). Alterations during pathogenesis cancer well documented (Hakomori 2002). under results creation cryptic carbohydrate core structures Tn, sialyl Tn T (Taylor-Papadimitriou 1999). Gram-negative bacterium Helicobacter pyroli infects over 50% world’s population causes various gastric diseases such as chronic gastritis, peptic ulcer Peripheral lymph node addressin (PNAd) containing 6-sulfo Lewis Xcapped O-glycans on high endothelial venule (HEV)-like vessels closely H pyroli-related diseases. ┙1,4 GlcNAc-capped expressed by gland mucous cell-derived prevents colonization pyroli. Thus, differential distinct stomach provides therapeutic potentialities based specific modulation (Nakayama 1999; Reis 2000 Kobayashi 2009). Werther (1996) examined frequency its prognostic value immunohistochemical analysis 340 tumors found a marker suggesting play role malignant tumor. Santos-Silva (2005) reported polymorphism MUC1 tandem repeat exerts aggressive tend express antigen. Immunohistochemical study Amado (1998) for dimeric Lewisx 97 carcinomas revealed correlation